4-FLUORO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE - Names and Identifiers
4-FLUORO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE - Physico-chemical Properties
Molecular Formula | C7H3ClF4O2S
|
Molar Mass | 262.61 |
Density | 1.603±0.06 g/cm3 (20 ºC 760 Torr) |
Boling Point | 92°C/0.8mm |
Flash Point | 121.2±27.3℃ |
Vapor Presure | 0.00791mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Sensitive | Moisture Sensitive |
Refractive Index | 1.4760 to 1.4800 |
MDL | MFCD01091001 |
Physical and Chemical Properties | Sensitivity: moiure Sensitive |
4-FLUORO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE - Risk and Safety
Risk Codes | 36 - Irritating to the eyes
|
Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
|
UN IDs | UN3265 |
Hazard Note | Corrosive |
Hazard Class | 8 |
Packing Group | II |
4-FLUORO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE - Introduction
4-FLUORO-3-(TRIFLUOROMETHYL) benzensulphonyl CHLORIDE is an organic compound with the chemical formula C7H3ClF4O2S. The following is a description of its nature, use, preparation and safety information:
Nature:
4-FLUORO-3-(TRIFLUOROMETHYL) benzensulphonyl CHLORIDE is a colorless to pale yellow liquid with a pungent odor. Insoluble in water, soluble in organic solvents. It is a strong oxidizer and caustic, reacting with water to produce hydrofluorosulfate and trifluoromethanesulfonic acid.
Use:
4-FLUORO-3-(TRIFLUOROMETHYL)BENZENESULPHONYL CHLORIDE can be used as a reaction reagent in organic synthesis, and is commonly used in the removal reaction of protecting groups of phenol and aromatic amines. It can replace the active hydrogen atoms in phenol and amine compounds with chlorine atoms, thus realizing the removal of sulfonyl chloride protecting groups.
Method:
The preparation method of 4-FLUORO-3-(TRIFLUOROMETHYL)BENZENESULPHONYL CHLORIDE is usually obtained by reacting 3-trifluoromethylbenzenesulfonyl CHLORIDE with boron tetrafluoride and butyl hydrofluoride. The specific reaction conditions and steps may vary, but generally the reaction is carried out at a low temperature and under the protection of an inert gas.
Safety Information:
4-FLUORO-3-(TRIFLUOROMETHYL) benzensulphonyl CHLORIDE is a strong corrosive compound, which is strongly irritating and corrosive. Contact with skin, eyes or inhalation of vapors can cause serious injury. During use or storage, care should be taken to avoid contact with water and moisture, avoid high temperatures and open flames. Wear appropriate protective equipment, such as chemical protective gloves, protective goggles and face shields. The operation must be carried out in a well-ventilated environment and avoid inhalation of its vapors. If you accidentally touch or ingest this substance, you should seek medical attention immediately.
Last Update:2024-04-10 22:29:15